South Park has been well-known for over a decade for satirizing pop culture in its own unique and pointed way - but there have been at least a couple times when they miss the mark. Not too surprising, given each episode is produced in about 6 days. Still, they hit so often that when they miss, it stands out. Here's a few times that it wasn't even clear whether they were familiar with the thing they were making fun of.
1. 'Game of Thrones' Nudity
Over the course of three episodes ("Black Friday" / "A Song of Ass and Fire" / "Titties and Dragons"), South Park took on Game of Thrones, through the lens of the Console War between Xbox and Playstation. And throughout the whole thing, there were constant references to the nudity in Game of Thrones - but not the female nudity, but the male nudity ("Wieners" specifically).
The thing is - Game of Thrones is sorta renowned for having wildly disproportionate amount of female nudity compared to male nudity. The only wieners seen on the show belong to Hodor (and...not in much of a sexual way), Theon (at one point sexual, then later...less sexual), the guy who tried to poison Daenerys (extremely non-sexual), and one of Craster's sons (VERY EXTREMELY NON-SEXUAL). Whereas the show constantly inundates you with all variety of female nudity and almost always in a sexual manner.