Turok 2: Seeds of Evil introduced a weapon that was not only ridiculously powerful, but almost cruelly so - the Cerebral Bore. You lock on, fire, and whatever you were shooting at is marked for death - but it doesn't happen quite so quickly. The shot bores a hole into your brain (as the title would suggest), spewing out a spray of blood and gore, and then it explodes, taking your head with it. It's a horrifying, multi-step trip to certain doom, and it's way more devastating than any other weapon in the game. When you're able to provide more horrifying deaths than hordes of monsters and dinosaurs, it's time to take a step back and figure out how you went from hero to Ted Bundy.
When you're presented with a shotgun, an assault rifle, and a pistol, and you pick up the pistol without hesitation, you should know something's up. For one thing, why is someone presenting you with guns? This can't be legal. You should probably get the hell out of wherever you are. Secondly, since when is a pistol better than two objectively more powerful weapons?
The pistol is may be the best weapon period in the original Halo - you can zoom in and take out anyone in sight with a few well-placed shots, they don't leave a trail like sniper rifles, and there's way more ammo than rocket launchers. In short, it's a devastatingly powerful weapon - which made it a little disappointing when it was scaled back to how a pistol should behave in the sequels. But maybe the most unfair thing about it was how much cooler the pistol-whip animation was than any other melee attack.
Perfect Dark, we're not done with you. As if the Laptop Gun wasn't enough, they went and put in an alien sniper rifle. An alien sniper rifle that could shoot through walls. An alien sniper rifle that could shoot through walls THAT WOULD EVEN AIM FOR YOU. Oh, and it was a one-hit kill.
James Bond can keep his wimpy Golden Gun.
In a game with exploding bananas, superpowered sheep, and napalm strikes, you might be wary to worry too much about a donkey made out of concrete - but there's nothing more horrifying than the sound of its "hee-haw"'s as it crushes everything in its path. If Worms is the goofy videogame equivalent of chess, as many experts (aka "just me") agree it is, the Concrete Donkey is that crazy gambit from Searching For Bobby Fischer. Even a worm that's burrowed deep underground, normally protected from anything you could throw at it, is totally vulnerable when the Concrete Donkey is dispatched. Pretty crazy to realize that's what those ringworms in your dog's stomach were up to this whole time.